•Decrease in the number of new substances identified for the first time in 2016 and 2017
•However, a large increase observed in:
•Availability of NPS in Europe
•Detections reported by law enforcement agencies
•Serious adverse events i.e. non-fatal intoxications, deaths and other harms
•Consumer groups of NPS have broadened
•Trend towards highly potent substances
•Growing interactions between the NPS and the established illicit drug market
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